NAD+ Subcutaneous Injection

What it is:

NAD⁺ stands for Nicotinamide Adenine Dinucleotide. It’s a coenzyme found in every cell of your body and plays a crucial role in:

1. Energy production – Helps convert the food you eat into energy (ATP) in your cells.
    
2. DNA repair – Supports the body’s natural repair of damaged DNA.
    
3. Cellular health and longevity – Involved in processes that regulate aging and cell function.
    
4. Metabolism – Helps enzymes work efficiently in breaking down fats, proteins, and carbohydrates.
    

In simple terms, NAD⁺ is like a fuel and repair helper for your cells, keeping them energized and healthy. 

Subcutaneous NAD+ injections are a way of delivering nicotinamide adenine dinucleotide (NAD+), a molecule involved in energy production and cellular repair, directly under the skin.

How it’s given:

• A small needle injects the NAD+ just under the skin, usually in the abdomen, thigh, or upper arm.
   
• Injections are typically done in a clinic or at home under supervision, depending on your treatment plan.
   

Potential benefits:

• Supports cellular energy and metabolism
   
• May help with fatigue and mental clarity
   
• Sometimes used in addiction recovery or wellness programs
   

What to expect:

• Mild discomfort, redness, or swelling at the injection site
   
• Rarely, bruising or irritation

Safety tips:

• Keep the injection site clean
   
• Rotate injection spots to avoid irritation
   
• Report any severe pain, swelling, or signs of infection to your healthcare provider immediately

NAD⁺ levels naturally decline as we age due to several biological processes:

1. Increased consumption by enzymes – Certain enzymes, like PARPs (involved in DNA repair) and CD38 (involved in inflammation and immune responses), use up NAD⁺. As we age, these enzymes become more active, depleting NAD⁺ faster.
    
2. Reduced synthesis – The body’s ability to make NAD⁺ from precursors like tryptophan, nicotinamide, and nicotinamide riboside diminishes with age.
    
3. Mitochondrial decline – Aging cells often have less efficient mitochondria, which affects NAD⁺ recycling, further lowering its levels.
    
4. Oxidative stress – Accumulated cellular damage over time increases NAD⁺ consumption because the body tries to repair more DNA and proteins.
    

Result: Lower NAD⁺ leads to reduced cellular energy, slower repair processes, and increased signs of aging, which is why some therapies aim to restore NAD⁺ levels.

• Methylcobalamin is a bioactive form of B12, meaning your body can use it directly without needing conversion.
   
• It’s often given as injections, sublingual tablets, or oral supplements.
   

1. Nerve health – Supports the formation and maintenance of the protective covering (myelin) around nerves.
    
2. Red blood cell production – Helps prevent certain types of anemia caused by B12 deficiency.
    
3. DNA and protein synthesis – Vital for normal cell division and repair.
    
4. Homocysteine regulation – Helps convert homocysteine (a compound linked to heart disease) into safer molecules.
    

• Supporting neuropathy (nerve pain), often in diabetes or other nerve disorders.
   
• Sometimes used for energy support and general wellness.
   

• Injection: Often into muscle or under the skin (subcutaneous). Works faster for deficiencies or nerve issues.
   
• Oral / Sublingual: Tablets or drops under the tongue; slower absorption but convenient.
   

• Usually well tolerated.
   
• Rarely: mild headache, nausea, dizziness, or injection-site pain.